Vignettes

1 Defining group-sequential boundaries with rpact

Published on: Do, 14-November-2019 - 09:34 By: Marcel Wolbers, Gernot Wassmer, and Friedrich Pahlke

This R Markdown document gives example code for the the definition of the most commonly used group-sequential boundaries in rpact.

2 Designing group-sequential trials with two groups and a continuous endpoint with rpact

Published on: Do, 14-November-2019 - 09:34 By: Dietmar Volz, Marcel Wolbers, Gernot Wassmer, and Friedrich Pahlke

This R Markdown document provides examples for designing trials with continuous endpoints using rpact.

3 Designing group-sequential trials with a binary endpoint with rpact

Published on: Do, 14-November-2019 - 09:34 By: Marcel Wolbers, Gernot Wassmer, and Friedrich Pahlke

This R Markdown document provides examples for designing trials with binary endpoints using rpact.

4 Designing group-sequential trials with two groups and a survival endpoint with rpact

Published on: Do, 14-November-2019 - 09:34 By: Marcel Wolbers, Gernot Wassmer, and Friedrich Pahlke

This R Markdown document provides examples for designing trials with survival endpoints with rpact.

5 Simulation-based design of group-sequential trials with a survival endpoint with rpact

Published on: Do, 14-November-2019 - 09:34 By: Marcel Wolbers, Gernot Wassmer, and Friedrich Pahlke

This R Markdown document describes how to simulate design characterics for survival design under complex settings (incl. non-proportional hazards) in rpact.

6 An example to illustrate boundary re-calculations during the trial

Published on: Do, 14-November-2019 - 09:34 By: Marcel Wolbers, Gernot Wassmer, and Friedrich Pahlke

This R Markdown document provides an example for updating the group sequential boundaries when using an alpha spending function approach based on observed information rates in rpact.

7 Analysis of a group-sequential trial with a survival endpoint

Published on: Do, 14-November-2019 - 09:34 By: Marcel Wolbers, Gernot Wassmer, and Friedrich Pahlke

This R Markdown document provides examples how to analyse a survival trial and provide inference throughout and at the end of the trial with rpact.

8 Defining accrual time and accrual intensity with rpact

Published on: Do, 14-November-2019 - 09:34 By: Gernot Wassmer and Friedrich Pahlke

This R Markdown document provides a technical view on the different alternatives to define accrual time and accrual intensity with rpact.

9 How to use R generics with rpact

Published on: Do, 14-November-2019 - 09:34 By: Gernot Wassmer and Friedrich Pahlke

This R Markdown document provides many different examples that illustrate the usage of so-called R generic functions (short: R generics) with rpact, e.g., as.data.frame or summary.

10 How to create admirable plots with rpact

Published on: Do, 14-November-2019 - 09:34 By: Gernot Wassmer and Friedrich Pahlke

This R Markdown document provides many different examples for creating plots with rpact and ggplot2, e.g. the plot arguments type and showSource will be illustrated.

11 Comparing sample size and power calculation results for a group-sequential trial with a survival endpoint: rpact vs. gsDesign

Published on: Do, 14-November-2019 - 09:34 By: Gernot Wassmer, Friedrich Pahlke, and Marcel Wolbers

This R Markdown document provides an example that illustrates how to compare sample size and power calculation results of the two different R packages rpact and gsDesign.

12 Supplementing and enhancing rpact's graphical capabilities with ggplot2

Published on: Do, 14-November-2019 - 09:34 By: Yannic Schmidt, Stefan Englert, Martina Kron, Gernot Wassmer, and Friedrich Pahlke

The aim of this R Markdown document is to give a brief description on how easy it is to supplement and enhance plots generated in rpact by use of the ggplot2 package and associated language.

13 Using the inverse normal combination test for analysing a trial with continuous endpoint and potential sample size reassessment

Published on: Do, 14-November-2019 - 09:34 By: Gernot Wassmer and Friedrich Pahlke

This R Markdown document provides an example for analysing trials with a continuous endpoint and sample size reassessment using rpact.

14 Planning a trial with binary endpoints with rpact

Published on: Do, 14-November-2019 - 09:34 By: Gernot Wassmer and Friedrich Pahlke

This R Markdown document provides an example for planning a trial with a binary endpoint using rpact. It also illustrates the use of ggplot2 for illustrating the characteristics of a sample size recalculation strategy. Another example for planning a trial with binary endpoints can be found here.

15 Planning a survival trial with rpact

Published on: Do, 14-November-2019 - 09:34 By: Gernot Wassmer and Friedrich Pahlke

This R Markdown document provides an example for planning a trial with a survival endpoint using rpact thereby illustrating the different ways of entering recruitment schemes. It also demonstrates the use of the survival simulation function.