Vignettes

Developed for practical use: below you find a collection of practical examples and use-cases, the so-called rpact vignettes.

In addition to these public open access vignettes, our RPACT SLA customers have access to exclusive vignettes on special topics such as the analysis of multi-stage data with covariates from raw data.

Two-arm Analysis for Continuous Data with Covariates from Raw Data using rpact
Analysis
Means
This document provides an example for importing raw data from a csv file, calculating estimated adjusted (marginal) means (EMMs, least-squares means) for a linear model, and performing two-arm interim analyses with these…
Friedrich Pahlke Gernot Wassmer
Oct 28, 2024

Using the Inverse Normal Combination Test for Analyzing a Trial with Continuous Endpoint and Potential Sample Size Re-Assessment with rpact
Analysis
Means
This document provides an example for analysing trials with a continuous endpoint and sample size reassessment using rpact.
Gernot Wassmer Friedrich Pahlke
Dec 6, 2024

Analysis of a Multi-Arm Design with a Binary Endpoint using rpact
Analysis
Rates
Multi-arm
This document shows how to analyse and interpret multi-arm designs for testing proportions with rpact.
Gernot Wassmer Friedrich Pahlke
Dec 6, 2024

Analysis of a Group Sequential Trial with a Survival Endpoint using rpact
Analysis
Survival
This document provides examples how to analyse a group sequential trial with a survival endpoint and provide inference throughout and at the end of the trial with rpact.
Marcel Wolbers Gernot Wassmer Friedrich Pahlke
Dec 6, 2024

Step-by-Step rpact Tutorial
Getting started
The R package rpact has been developed to design sequential and adaptive experiments. Many of the functions of the R package are available in an online [Shiny…
Daniel Lakens Friedrich Pahlke Gernot Wassmer
Dec 6, 2024

Defining Group Sequential Boundaries with rpact
Planning
This document provides example code for the the definition of the most commonly used group sequential boundaries in rpact.
Marcel Wolbers Gernot Wassmer Friedrich Pahlke
Dec 6, 2024

Delayed Response Designs with rpact
Planning
This document provides a brief introduction to group sequential designs with delayed responses as proposed by Hampson and Jennison (2013). It is shown how this is implemented in…
Stephen Schueuerhuis Gernot Wassmer Friedrich Pahlke
Dec 6, 2024

Count Data with rpact
Planning
Count Data
This document describes how sample size and power calculations for count data can be performed using rpact. This is shown for the fixed sample and the group sequential case…
Gernot Wassmer Tobias Muetze Friedrich Pahlke
Dec 6, 2024

Designing Group Sequential Trials with Two Groups and a Continuous Endpoint with rpact
Planning
Means
This document provides examples for designing trials with continuous endpoints using rpact.
Dietmar Volz Marcel Wolbers Gernot Wassmer Friedrich Pahlke
Dec 6, 2024

Simulating Multi-Arm Designs with a Continuous Endpoint using rpact
Planning
Means
Power simulation
Multi-arm
This document provides examples for simulating multi-arm multi-stage (MAMS) designs for testing means with rpact.
Gernot Wassmer Friedrich Pahlke
Oct 28, 2024

Designing Group Sequential Trials with a Binary Endpoint with rpact
Planning
Rates
This document provides examples for designing trials with binary endpoints using rpact.
Marcel Wolbers Gernot Wassmer Friedrich Pahlke
Dec 6, 2024

Enrichment Designs for Testing Rates with rpact
Planning
Rates
Analysis
Enrichment
This document provides examples for simulating test characteristics for multi-stage enrichment designs for testing rates with rpact. Specifically, it is shown how to obtain the…
Gernot Wassmer Friedrich Pahlke
Dec 2, 2024

Planning and Analyzing a Group-Sequential Multi-Arm Multi-Stage Design with Binary Endpoint using rpact
Planning
Rates
Multi-arm
Analysis
This document provides an example of implementing, simulating and analyzing multi-arm-multi-stage (MAMS) designs for testing rates with rpact with special regards to futility…
Stephen Schueuerhuis Gernot Wassmer Friedrich Pahlke
Oct 28, 2024

Planning a Trial with Binary Endpoints with rpact
Planning
Rates
Sample size
Power simulation
This document provides an example for planning a trial with a binary endpoint using rpact. It also illustrates the use of ggplot2 for illustrating…
Gernot Wassmer Friedrich Pahlke
Dec 6, 2024

Simulation of a Trial with a Binary Endpoint and Unblinded Sample Size Re-Calculation with rpact
Planning
Rates
Sample size
Power simulation
This document provides examples for assessing trials with adaptive sample size re-calculation (SSR) using rpact. It also shows how to implement the promizing zone approach as…
Marcel Wolbers Gernot Wassmer Friedrich Pahlke
Oct 28, 2024

Promizing Zone Design with rpact
Planning
Simulation
We demonstrate how ‘rpact’ enables users to easily define new functions for calculating the number of subjects or events required, based on given conditional power and critical values for specific testing scenarios. This…
Gernot Wassmer Friedrich Pahlke
Oct 28, 2024

An Example to Illustrate Boundary Re-Calculations during the Trial with rpact
Planning
Survival
This document provides an example for updating the group sequential boundaries when using an \(\alpha\)-spending function approach based on observed information rates in rpact.…
Marcel Wolbers Gernot Wassmer Friedrich Pahlke
Dec 6, 2024

Comparing Sample Size and Power Calculation Results for a Group Sequential Trial with a Survival Endpoint: rpact vs. gsDesign
Planning
Survival
This document provides an example that illustrates how to compare sample size and power calculation results of the two different R packages rpact and…
Gernot Wassmer Friedrich Pahlke Marcel Wolbers
Oct 28, 2024

Designing Group Sequential Trials with Two Groups and a Survival Endpoint with rpact
Planning
Survival
This document provides examples for designing trials with survival endpoints using rpact.
Marcel Wolbers Gernot Wassmer Friedrich Pahlke
Oct 28, 2024

Simulation-Based Design of Group Sequential Trials with a Survival Endpoint with rpact
Planning
Survival
Power simulation
This document describes how to simulate design characterics for survival design under complex settings (incl. non-proportional hazards) in rpact.
Marcel Wolbers Gernot Wassmer Friedrich Pahlke
Oct 28, 2024

Planning a Survival Trial with rpact
Planning
Survival
Sample size
Power simulation
This document provides an example for planning a trial with a survival endpoint using rpact thereby illustrating the different ways of entering recruitment schemes. It also…
Gernot Wassmer Friedrich Pahlke
Oct 28, 2024

How to Create One- and Multi-Arm Analysis Result Plots with rpact
Utilities
This document provides different examples for creating one- and multi-arm analysis result plots with rpact and ggplot2.
Friedrich Pahlke Gernot Wassmer
Oct 28, 2024

How to Create Summaries with rpact
Utilities
This document provides many different examples that illustrate the usage of the R generic function summary with rpact. This is a technical vignette and is to be considered…
Friedrich Pahlke Gernot Wassmer
Oct 28, 2024

How to use R Generics with rpact
Utilities
This document provides examples that illustrate the usage of R generic functions (short: R generics) with rpact, e.g., as.data.frame or summary.
Friedrich Pahlke Gernot Wassmer
Oct 28, 2024

Installation Qualification of rpact
Utilities
This document explains how to perform the Installation Qualification for rpact and highlights the recent changes to the testing process.
Friedrich Pahlke Gernot Wassmer
Dec 6, 2024

Supplementing and Enhancing rpact’s Graphical Capabilities with ggplot2
Utilities
Means
Power simulation
The aim of this document is to give a brief description on how easy it is to supplement and enhance plots generated in rpact by use of the…
Yannic Schmidt Stefan Englert Martina Kron Gernot Wassmer Friedrich Pahlke
Oct 28, 2024

How to Create One- and Multi-Arm Simulation Result Plots with rpact
Utilities
Power simulation
Multi-arm
This document provides many different examples for creating one- and multi-arm as well as enrichment simulation result plots with rpact and…
Friedrich Pahlke Gernot Wassmer
Oct 28, 2024

How to Create Admirable Plots with rpact
Utilities
Sample size
Power simulation
This document provides many different examples for creating plots with rpact and ggplot2.
Friedrich Pahlke Gernot Wassmer
Oct 28, 2024

Defining Accrual Time and Accrual Intensity with rpact
Utilities
Survival
This document provides a technical overview on the different alternatives to define accrual time and accrual intensity with rpact.
Friedrich Pahlke Gernot Wassmer
Oct 28, 2024
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